This course explores the impact of animal-assisted interactions on the quality of life for children with relapsed or refractory cancer and their parents, drawing on findings from a randomized controlled pilot study. Participants will examine the study’s purpose, design, and methodology, focusing on how animal-assisted sessions—conducted weekly for about fifteen minutes—were integrated into pediatric oncology care. The course will interpret health-related quality of life outcomes, analyze challenges in measuring these outcomes, and discuss the differences between child self-reports and parental reports. Learners will also consider the limitations of current assessment tools, such as the inclusion of irrelevant items for this patient population, and review the main strengths of the research, including its targeted design. The course concludes by formulating implications for future studies and potential integration of animal-assisted therapy into pediatric oncology nursing practice, emphasizing the need for larger samples and refined measures to advance the field.